Reactome | Pregn-5-ene-3,20-dione isomerizes to progesterone

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Pregn-5-ene-3,20-dione isomerizes to progesterone Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:193169] steroid Delta-isomerase activity of HSD3B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193053] Jassal, B, 2007-02-13 10:16:33
crossReference	[DatabaseIdentifier:12668256] RHEA:43929
dbId	193052
displayName	Pregn-5-ene-3,20-dione isomerizes to progesterone
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
eventOf	[Pathway:R-HSA-193993] Mineralocorticoid biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-193964] CYP21A2 21-hydroxylates PROG - Homo sapiens [Reaction:R-HSA-193072] CYP17A1 17-hydroxylates P4 to 17aHPROG - Homo sapiens
input	[SimpleEntity:R-ALL-196344] pregn-5-ene-3,20-dione [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:192183] Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells [LiteratureReference:196332] Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes [LiteratureReference:196346] Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads [LiteratureReference:196356] Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Pregn-5-ene-3,20-dione isomerizes to progesterone
orthologousEvent	[Reaction:R-DME-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - Drosophila melanogaster [Reaction:R-DRE-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - Danio rerio [Reaction:R-SSC-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - Sus scrofa [Reaction:R-BTA-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - Bos taurus [Reaction:R-CFA-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - Canis familiaris [Reaction:R-RNO-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - Rattus norvegicus [Reaction:R-MMU-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - Mus musculus
output	[SimpleEntity:R-ALL-193055] P4 [cytosol]
precedingEvent	[Reaction:R-HSA-196350] Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-1449722] Positive regulation by 'glyco-Lutropin [extracellular region]'
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193052
summation	[Summation:193122] Pregn-5-ene-3,20-dione isomerizes to progesterone. This reac...
updateTrackers	[UpdateTracker:9789370] Update Tracker - [Reaction:193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - v38:[addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789370] Update Tracker - [Reaction:193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - v38:[addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-193993] Mineralocorticoid biosynthesis
(precedingEvent)	[Reaction:R-HSA-193964] CYP21A2 21-hydroxylates PROG [Reaction:R-HSA-193072] CYP17A1 17-hydroxylates P4 to 17aHPROG

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