Reactome | The signal peptide is excised from pre-pro-NGF

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:181807] serine-type endopeptidase activity of convertase (Calcium dependant) [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:181805] Jassal, Bijay, 2006-06-20
dbId	181788
displayName	The signal peptide is excised from pre-pro-NGF
followingEvent	[Reaction:R-MMU-181822] pro-NGF dimerizes - Mus musculus
input	[DefinedSet:R-MMU-181832] pre-pro-NGF precursor [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:167035] Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector [LiteratureReference:167059] Dissociation equilibrium constant of beta nerve growth factor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The signal peptide is excised from pre-pro-NGF
orthologousEvent	[Reaction:R-HSA-187045] The signal peptide is excised from beta-NGF pre-pro-precursor - Homo sapiens
output	[DefinedSet:R-MMU-187019] pro-NGF precursor [endoplasmic reticulum lumen]
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-181788
summation	[Summation:167040] Pre-pro- precursors of the neurotrophins NGF, BDNF, NT-3, NT...
updateTrackers	[UpdateTracker:9792108] Update Tracker - [Reaction:181788] The signal peptide is excised from pre-pro-NGF - v24:[addSummation]

(updatedInstance)	[UpdateTracker:9792108] Update Tracker - [Reaction:181788] The signal peptide is excised from pre-pro-NGF - v24:[addSummation]
(precedingEvent)	[Reaction:R-MMU-181822] pro-NGF dimerizes

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