Reactome | EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9999720
displayName	EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane]
hasComponent	[Complex:R-MMU-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [DefinedSet:R-MMU-9038479] GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-162563] PTPN11 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Homo sapiens
maxDepth	5
name	EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2
producedByEvent	[Reaction:R-MMU-177924] Dephosphorylation of Gab1 by SHP2 - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-180503
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-MMU-177924] Dephosphorylation of Gab1 by SHP2
(inferredTo)	[Complex:R-HSA-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane]

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