Reactome | EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane]

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EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:180508] Jassal, B, 2006-05-23 09:31:46
dbId	180503
displayName	EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane]
hasComponent	[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [DefinedSet:R-HSA-9038479] GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-162563] PTPN11 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Mus musculus [Complex:R-RNO-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Canis familiaris [Complex:R-BTA-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Bos taurus [Complex:R-SSC-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Sus scrofa [Complex:R-XTR-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Gallus gallus [Complex:R-DME-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Drosophila melanogaster
maxDepth	5
modified	[InstanceEdit:9624451] Rothfels, Karen, 2018-10-11
name	EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 SHP2-GRB2:Phospho GAB1(dephos)-EGF-Phospho-EGFR dimer
producedByEvent	[Reaction:R-HSA-177924] Dephosphorylation of Gab1 by SHP2 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-180503
updateTrackers	[UpdateTracker:9894252] Update Tracker - [Complex:180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - v57:[updateContainedComponent] [UpdateTracker:9871971] Update Tracker - [Complex:180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - v41:[updateContainedComponent] [UpdateTracker:9870976] Update Tracker - [Complex:180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - v39:[updateContainedComponent] [UpdateTracker:9870375] Update Tracker - [Complex:180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - v38:[addName, updateContainedComponent] [UpdateTracker:9899836] Update Tracker - [Complex:180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - v67:[add_removeHasComponent, modifyName, updateContainedComponent] [UpdateTracker:9898551] Update Tracker - [Complex:180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - v64:[add_removeHasComponent]

Referrals

(updatedInstance)

(output)

[Reaction:R-HSA-177924] Dephosphorylation of Gab1 by SHP2

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