Reactome | phospho-Clspn [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-MMU-176182] Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] - Mus musculus [Complex:R-MMU-5684883] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] - Mus musculus
consumedByEvent	[Reaction:R-MMU-5684882] CHEK1 is recruited to resected DNA DSBs - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9999363
displayName	phospho-Clspn [nucleoplasm]
endCoordinate	1339
hasModifiedResidue	[ModifiedResidue:9999360] O-phospho-L-serine at 945 (in Homo sapiens) [ModifiedResidue:9999361] O-phospho-L-threonine at 916 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-176296] p-T916,S945-CLSPN [nucleoplasm] - Homo sapiens
maxDepth	1
name	phospho-Clspn p-T916,S945-CLSPN Q80YR7
producedByEvent	[Reaction:R-MMU-5684887] Activation of CHEK1 at resected DNA DSBs - Mus musculus
referenceEntity	[ReferenceGeneProduct:uniprot:Q80YR7] UniProt:Q80YR7
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-176296
startCoordinate	1

(hasComponent)	[Complex:R-MMU-176182] Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] [Complex:R-MMU-5684883] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]
(output)	[Reaction:R-MMU-5684887] Activation of CHEK1 at resected DNA DSBs
(input)	[Reaction:R-MMU-5684882] CHEK1 is recruited to resected DNA DSBs
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-176296] p-T916,S945-CLSPN [nucleoplasm]

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