Reactome | Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases

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Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases Show undefined attributes

catalystActivity	[CatalystActivity:9997297] phosphoprotein phosphatase activity of CDC25 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9997299
displayName	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
eventOf	[Pathway:R-MMU-69273] Cyclin A/B1/B2 associated events during G2/M transition - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-174132] Free APC/C phosphorylated by Cyclin B:Cdc2 - Mus musculus [Reaction:R-MMU-2294600] CDK1 phosphorylates condensin II subunit NCAPD3 - Mus musculus [Reaction:R-MMU-5195402] CDK1 phosphorylates LPIN - Mus musculus [Reaction:R-MMU-380278] CCNB1:p-T160-CDK1 phosphorylates NUMA1 - Mus musculus [Reaction:R-MMU-9009282] CDK1 phosphorylates RUNX2 - Mus musculus [Reaction:R-MMU-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Mus musculus [Reaction:R-MMU-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Mus musculus [Reaction:R-MMU-4088024] CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 - Mus musculus [Reaction:R-MMU-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Mus musculus
inferredFrom	[Reaction:R-HSA-170153] Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases - Homo sapiens
input	[Complex:R-MMU-170065] CCNB1:p-T14,Y15,T161-CDK1 [nucleoplasm] 2 × [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
output	[Complex:R-MMU-170160] CCNB1:p-T161-CDK1 [nucleoplasm] 2 × [SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
precedingEvent	[Reaction:R-MMU-170159] Translocation of Cdc25 to the nucleus - Mus musculus [Reaction:R-MMU-170131] Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes - Mus musculus [Reaction:R-MMU-156699] Inactivation of Wee1 kinase - Mus musculus [Reaction:R-MMU-170044] Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus - Mus musculus [Reaction:R-MMU-170149] Translocation of active Cdc25C to the nucleus - Mus musculus [Reaction:R-MMU-170070] Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-170153
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-174132] Free APC/C phosphorylated by Cyclin B:Cdc2 [Reaction:R-MMU-2294600] CDK1 phosphorylates condensin II subunit NCAPD3 [Reaction:R-MMU-5195402] CDK1 phosphorylates LPIN [Reaction:R-MMU-380278] CCNB1:p-T160-CDK1 phosphorylates NUMA1 [Reaction:R-MMU-9009282] CDK1 phosphorylates RUNX2 [Reaction:R-MMU-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 [Reaction:R-MMU-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex [Reaction:R-MMU-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 [Reaction:R-MMU-4088024] CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1
(hasEvent)	[Pathway:R-MMU-69273] Cyclin A/B1/B2 associated events during G2/M transition
(inferredTo)	[Reaction:R-HSA-170153] Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases

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