Reactome | Ampk phosphorylates Ppargc1a

Schema > Reaction > Entries

Ampk phosphorylates Ppargc1a Show undefined attributes

authored	[InstanceEdit:1592417] May, B, 2011-09-09
catalystActivity	[CatalystActivity:1605499] AMP-activated protein kinase activity of Ampk:AMP [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643356] AMP-activated protein kinase activity of Ampk:AMP [nucleoplasm] AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1605406] May, B, 2011-09-21
dbId	1605475
displayName	Ampk phosphorylates Ppargc1a
edited	[InstanceEdit:1592417] May, B, 2011-09-09
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-556791] Ppargc1a [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1605449] AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha [LiteratureReference:1592184] AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity [LiteratureReference:1606754] Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ampk phosphorylates Ppargc1a
orthologousEvent	[Reaction:R-HSA-1592244] AMPK phosphorylates PPARGC1A - Homo sapiens
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-1605429] p-T177,S538-Ppargc1a [nucleoplasm]
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5210062] Lezza, Angela M S, 2013-12-07
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1605475
summation	[Summation:1605441] AMPK is activated by AMP and phosphorylates Pgc-1alpha (Ppar...