Reactome | CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2

Schema > Reaction > Entries

CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 Show undefined attributes

catalystActivity	[CatalystActivity:10033166] carbonate dehydratase activity of CA1:Zn2+,CA2:Zn2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10033170
displayName	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2
eventOf	[Pathway:R-MMU-1247673] Erythrocytes take up oxygen and release carbon dioxide - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1247649] AQP1 tetramer transports CO2 from cytosol to extracellular region - Mus musculus [Reaction:R-MMU-1247645] RHAG transports CO2 from cytosol to extracellular region - Mus musculus
inferredFrom	[Reaction:R-HSA-1475436] CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-111627] HCO3- [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 Carbonic anhydrase I/II dehydrates bicarbonate
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent	[Reaction:R-MMU-1247668] Hemoglobin A binds O2, releasing H+ and CO2 - Mus musculus [Reaction:R-MMU-1247665] SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1475436
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1247673] Erythrocytes take up oxygen and release carbon dioxide
(precedingEvent)	[Reaction:R-MMU-1247649] AQP1 tetramer transports CO2 from cytosol to extracellular region [Reaction:R-MMU-1247645] RHAG transports CO2 from cytosol to extracellular region
(inferredTo)	[Reaction:R-HSA-1475436] CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2

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