Reactome | Hemoglobin A binds O2, releasing H+ and CO2

Schema > Reaction > Entries

Hemoglobin A binds O2, releasing H+ and CO2 Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10029453
displayName	Hemoglobin A binds O2, releasing H+ and CO2
eventOf	[Pathway:R-MMU-1247673] Erythrocytes take up oxygen and release carbon dioxide - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1475436] CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 - Mus musculus [Reaction:R-MMU-1247649] AQP1 tetramer transports CO2 from cytosol to extracellular region - Mus musculus [Reaction:R-MMU-1247645] RHAG transports CO2 from cytosol to extracellular region - Mus musculus
inferredFrom	[Reaction:R-HSA-1247668] Hemoglobin A binds O2, releasing H+ and CO2 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29368] O2 [cytosol] [Complex:R-MMU-1237312] Protonated Carbamino DeoxyHbA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Hemoglobin A binds O2, releasing H+ and CO2 Hemoglobin A binds oxygen and releases protons and carbon dioxide Haldane Effect
output	4 × [SimpleEntity:R-ALL-113528] CO2 [cytosol] 4 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [Complex:R-MMU-1237320] OxyHbA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1247668
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1247673] Erythrocytes take up oxygen and release carbon dioxide
(precedingEvent)	[Reaction:R-MMU-1247649] AQP1 tetramer transports CO2 from cytosol to extracellular region [Reaction:R-MMU-1247645] RHAG transports CO2 from cytosol to extracellular region [Reaction:R-MMU-1475436] CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2
(inferredTo)	[Reaction:R-HSA-1247668] Hemoglobin A binds O2, releasing H+ and CO2

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