Reactome | Cleavage of Procaspase-7 by the apoptosome

Schema > Reaction > Entries

Cleavage of Procaspase-7 by the apoptosome Show undefined attributes

catalystActivity	[CatalystActivity:9992810] cysteine-type endopeptidase activity of Apoptosome [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9992860
displayName	Cleavage of Procaspase-7 by the apoptosome
eventOf	[Pathway:R-MMU-111459] Activation of caspases through apoptosome-mediated cleavage - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9627107] XIAP binds CASP7 - Mus musculus [BlackBoxEvent:R-MMU-9029680] Caspase-7 translocates to the nucleus - Mus musculus [Reaction:R-MMU-201634] Caspase-mediated cleavage of FADK 1 - Mus musculus [Reaction:R-MMU-201628] Caspase-mediated cleavage of vimentin at DSVD (85) - Mus musculus [Reaction:R-MMU-201639] Caspase-mediated cleavage of GAS2 - Mus musculus
inferredFrom	[Reaction:R-HSA-114261] Cleavage of Procaspase-7 by the apoptosome - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-6804324] CASP7(2-303) dimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cleavage of Procaspase-7 by the apoptosome
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-141643] Caspase-7 [cytosol]
precedingEvent	[Reaction:R-MMU-114259] Cleavage of Procaspase?9 to caspase?9 - Mus musculus
regulatedBy	[NegativeRegulation:9992813] Negative regulation by 'XIAP [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-114261
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-9627107] XIAP binds CASP7 [BlackBoxEvent:R-MMU-9029680] Caspase-7 translocates to the nucleus [Reaction:R-MMU-201628] Caspase-mediated cleavage of vimentin at DSVD (85) [Reaction:R-MMU-201639] Caspase-mediated cleavage of GAS2 [Reaction:R-MMU-201634] Caspase-mediated cleavage of FADK 1
(hasEvent)	[Pathway:R-MMU-111459] Activation of caspases through apoptosome-mediated cleavage
(inferredTo)	[Reaction:R-HSA-114261] Cleavage of Procaspase-7 by the apoptosome