Reactome | Cleavage of Procaspase?9 to caspase?9

Schema > Reaction > Entries

Cleavage of Procaspase?9 to caspase?9 Show undefined attributes

catalystActivity	[CatalystActivity:9992842] cysteine-type endopeptidase activity of APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9992844
displayName	Cleavage of Procaspase?9 to caspase?9
eventOf	[Pathway:R-MMU-111458] Formation of apoptosome - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9627078] XIAP binds CASP9 - Mus musculus [Reaction:R-MMU-114261] Cleavage of Procaspase-7 by the apoptosome - Mus musculus [Reaction:R-MMU-114252] Cleavage of Procaspase-3 by the apoptosome - Mus musculus
inferredFrom	[Reaction:R-HSA-114259] Cleavage of Procaspase?9 to caspase?9 - Homo sapiens
input	[Complex:R-MMU-6804630] APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cleavage of Procaspase?9 to caspase?9
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-114258] Apoptosome [cytosol]
precedingEvent	[Reaction:R-MMU-9627056] Procaspase 9 forms dimer - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-114259
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-111458] Formation of apoptosome
(precedingEvent)	[Reaction:R-MMU-9627078] XIAP binds CASP9 [Reaction:R-MMU-114261] Cleavage of Procaspase-7 by the apoptosome [Reaction:R-MMU-114252] Cleavage of Procaspase-3 by the apoptosome
(inferredTo)	[Reaction:R-HSA-114259] Cleavage of Procaspase?9 to caspase?9

Cite Us!