Reactome | GATA3 regulates expression of IL5

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GATA3 regulates expression of IL5 Show undefined attributes

authored	[InstanceEdit:9976368] May, Bruce, 2025-12-11
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:9976404] May, Bruce, 2025-12-11
dbId	9976371
displayName	GATA3 regulates expression of IL5
edited	[InstanceEdit:9976368] May, Bruce, 2025-12-11
eventOf	[Pathway:R-HSA-9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9978105] Gata3 regulates the Il5 gene - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-9976400] IL5 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9976401] GATA-3 has dual regulatory functions in human interleukin-5 transcription
maxDepth	1
modified	[InstanceEdit:9983731] May, Bruce, 2026-02-26
name	GATA3 regulates expression of IL5
output	[EntityWithAccessionedSequence:R-HSA-447159] IL5 [extracellular region]
precedingEvent	[Reaction:R-HSA-9976390] GATA3 binds the IL5 gene - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9976389] Positive gene expression regulation by 'GATA3:IL5 gene [nucleoplasm]'
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9983436] Barbutti, Isabella, 2026-02-24 [InstanceEdit:9983730] Lord, Graham M, 2026-02-26
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9976371
summation	[Summation:9976395] GATA3 bound to 3 sites in the promoter of the IL5 gene regul...

Referrals

(hasEvent)	[Pathway:R-HSA-9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)
(inferredTo)	[BlackBoxEvent:R-MMU-9978105] Gata3 regulates the Il5 gene

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