Reactome | MLL1:MEN1:p-Y641-STAT6:p-S243-NFATC2:Notch1,2 Coactivator:GATA3 gene [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9976111] May, Bruce, 2025-12-08
dbId	9976109
displayName	MLL1:MEN1:p-Y641-STAT6:p-S243-NFATC2:Notch1,2 Coactivator:GATA3 gene [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-6786283] GATA3 gene [nucleoplasm] [Complex:R-HSA-9818943] MLL1 complex:MEN1 [nucleoplasm] [Complex:R-HSA-9977595] NOTCH1,2 Coactivator Complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2025894] p-S243-NFATC2 [nucleoplasm] [Complex:R-HSA-6786281] p-Y641-STAT6 dimer [nucleoplasm]
inDisease	false
isChimeric	false
maxDepth	5
modified	[InstanceEdit:9977606] May, Bruce, 2025-12-22
name	MLL1:MEN1:p-Y641-STAT6:p-S243-NFATC2:Notch1,2 Coactivator:GATA3 gene
positivelyRegulates	[PositiveGeneExpressionRegulation:9976145] Positive gene expression regulation by 'MLL1:MEN1:p-Y641-STAT6:p-S243-NFATC2:Notch1,2 Coactivator:GATA3 gene [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-9976117] STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9976109

(output)	[Reaction:R-HSA-9976117] STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2)
(regulator)	[PositiveGeneExpressionRegulation:9976145] Positive gene expression regulation by 'MLL1:MEN1:p-Y641-STAT6:p-S243-NFATC2:Notch1,2 Coactivator:GATA3 gene [nucleoplasm]'

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