Reactome | Unknown CYP 450 omega-hydroxylates C10 fatty acid

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Unknown CYP 450 omega-hydroxylates C10 fatty acid Show undefined attributes

authored	[InstanceEdit:9971243] Stephan, Ralf, 2025-11-05
catalystActivity	[CatalystActivity:9971240] monooxygenase activity of Unknown Cytochrome P450-like monooxygenase [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:9971234] Stephan, Ralf, 2025-11-05
crossReference	[DatabaseIdentifier:9971237] RHEA:75284
dbId	9971246
displayName	Unknown CYP 450 omega-hydroxylates C10 fatty acid
edited	[InstanceEdit:9984514] Stephan, Ralf, 2026-03-09
eventOf	[Pathway:R-HSA-211935] Fatty acids - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:534] fatty acid metabolic process
input	[SimpleEntity:R-ALL-422019] DECA [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:211851] Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes [LiteratureReference:9971241] On the biologic origin of C6-C10-dicarboxylic and C6-C10-omega-1-hydroxy monocarboxylic acids in human and rat with acyl-CoA dehydrogenation deficiencies: in vitro studies on the omega- and omega-1-oxidation of medium-chain (C6-C12) fatty acids in human and rat liver
maxDepth	1
modified	[InstanceEdit:9984515] Stephan, Ralf, 2026-03-09
name	Unknown CYP 450 omega-hydroxylates C10 fatty acid decanoic acid + O₂ + NADPH -> 10-hydroxydecanoic acid + H₂O + NADP⁺ + H⁺
output	[SimpleEntity:R-ALL-9971242] 10-OH-DECA [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9981792] D'Eustachio, Peter, 2026-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9971246
summation	[Summation:9971236] An unknown cytochrome P450 hydroxylates decanoate (C10 fatty...

Referrals

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[Pathway:R-HSA-211935] Fatty acids

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