Reactome | Hormone receptor positive mammary luminal progenitor cell produces hormone receptor positive luminal epithelial cell

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Hormone receptor positive mammary luminal progenitor cell produces hormone receptor positive luminal epithelial cell Show undefined attributes

authored	[InstanceEdit:9925818] Qiao, Jingping, 2024-10-15
category	transition
created	[InstanceEdit:9960181] Orlic-Milacic, Marija, 2025-07-07
dbId	9960183
displayName	Hormone receptor positive mammary luminal progenitor cell produces hormone receptor positive luminal epithelial cell
edited	[InstanceEdit:9963947] Orlic-Milacic, Marija, 2025-08-18
eventOf	[CellLineagePath:R-HSA-9927418] Developmental Lineage of Mammary Gland Luminal Epithelial Cells - Homo sapiens
input	[Cell:R-HSA-9960159] hormone receptor positive mammary luminal progenitor cell
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9945210] The CD10 enzyme is a key player to identify and regulate human mammary stem cells [LiteratureReference:9941947] Distinct effects of EGFR ligands on human mammary epithelial cell differentiation [LiteratureReference:9941885] Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue [LiteratureReference:9947265] Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue [LiteratureReference:9941977] Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast
maxDepth	1
modified	[InstanceEdit:9964069] Orlic-Milacic, Marija, 2025-08-19
name	Hormone receptor positive mammary luminal progenitor cell produces hormone receptor positive luminal epithelial cell
output	[Cell:R-HSA-9960188] hormone receptor positive mammary luminal epithelial cell
precedingEvent	[CellDevelopmentStep:R-HSA-9960175] Mammary stem cell produces hormone receptor positive luminal progenitor cell - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveRegulation:9725602] Positive regulation by 'EGF [extracellular region]' [PositiveRegulation:9946679] Positive regulation by 'AREG [extracellular region]' [PositiveRegulation:9632181] Positive regulation by 'ESTG [extracellular region]'
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9964066] Qiao, Jingping, 2025-08-26
schemaClass	CellDevelopmentStep
species	[Species:48887] Homo sapiens
stId	R-HSA-9960183
summation	[Summation:9960185] ESR+ luminal progenitors give rise to mature luminal cell...

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(hasEvent)

[CellLineagePath:R-HSA-9927418] Developmental Lineage of Mammary Gland Luminal Epithelial Cells

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