Reactome | SLC-mediated transport of inorganic anions

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SLC-mediated transport of inorganic anions Show undefined attributes

authored	[InstanceEdit:9958701] Stephan, Ralf, 2025-06-24
created	[InstanceEdit:9958791] Stephan, Ralf, 2025-06-25
crossReference	[DatabaseIdentifier:12819499] BioModels Database:BIOMD0000000327
dbId	9958790
deleted	[Deleted:9960232] Deletion of instance: 425393 [Deleted:9608154] Deletion of instance: 425374
diseasePathways	[Pathway:R-HSA-5619104] Defective SLC12A1 causes Bartter syndrome 1 (BS1) - Homo sapiens [Pathway:R-HSA-5619111] Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) - Homo sapiens [Pathway:R-HSA-5619087] Defective SLC12A3 causes Gitelman syndrome (GS) - Homo sapiens [Pathway:R-HSA-5619085] Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) - Homo sapiens [Pathway:R-HSA-5619039] Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) - Homo sapiens [Pathway:R-HSA-5619045] Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) - Homo sapiens [Pathway:R-HSA-5619046] Defective SLC26A4 causes Pendred syndrome (PDS) - Homo sapiens [Pathway:R-HSA-5619040] Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) - Homo sapiens [Pathway:R-HSA-5619054] Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) - Homo sapiens [Pathway:R-HSA-5619097] Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) - Homo sapiens [Pathway:R-HSA-5619096] Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) - Homo sapiens
displayName	SLC-mediated transport of inorganic anions
edited	[InstanceEdit:9963147] Stephan, Ralf, 2025-08-13
eventOf	[Pathway:R-HSA-425407] SLC-mediated transmembrane transport - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:259583] transmembrane transport
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-425381] Bicarbonate transporters - Homo sapiens [Pathway:R-HSA-433137] Sodium-coupled sulphate, di- and tri-carboxylate transporters - Homo sapiens [Pathway:R-HSA-426117] Cation-coupled Chloride cotransporters - Homo sapiens [Pathway:R-HSA-427601] Inorganic anion exchange by SLC26 transporters - Homo sapiens [Pathway:R-HSA-427652] Sodium-coupled phosphate cotransporters - Homo sapiens [Reaction:R-HSA-429591] SLC5A5 cotransports Na+ with I- from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-429767] Passive I- efflux mediated by SLC5A8 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:433768] Proximal tubular handling of phosphate: A molecular perspective [LiteratureReference:427636] Phosphate transporters: a tale of two solute carrier families [LiteratureReference:433145] SLC4 base (HCO3 -, CO3 2-) transporters: classification, function, structure, genetic diseases, and knockout models [LiteratureReference:426105] Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family [LiteratureReference:427623] The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors
maxDepth	4
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SLC-mediated transport of inorganic anions
orthologousEvent	[Pathway:R-MMU-9958790] SLC-mediated transport of inorganic anions - Mus musculus [Pathway:R-RNO-9958790] SLC-mediated transport of inorganic anions - Rattus norvegicus [Pathway:R-CFA-9958790] SLC-mediated transport of inorganic anions - Canis familiaris [Pathway:R-BTA-9958790] SLC-mediated transport of inorganic anions - Bos taurus [Pathway:R-SSC-9958790] SLC-mediated transport of inorganic anions - Sus scrofa [Pathway:R-DRE-9958790] SLC-mediated transport of inorganic anions - Danio rerio [Pathway:R-XTR-9958790] SLC-mediated transport of inorganic anions - Xenopus tropicalis [Pathway:R-GGA-9958790] SLC-mediated transport of inorganic anions - Gallus gallus [Pathway:R-DME-9958790] SLC-mediated transport of inorganic anions - Drosophila melanogaster [Pathway:R-CEL-9958790] SLC-mediated transport of inorganic anions - Caenorhabditis elegans [Pathway:R-DDI-9958790] SLC-mediated transport of inorganic anions - Dictyostelium discoideum [Pathway:R-SPO-9958790] SLC-mediated transport of inorganic anions - Schizosaccharomyces pombe [Pathway:R-SCE-9958790] SLC-mediated transport of inorganic anions - Saccharomyces cerevisiae [Pathway:R-PFA-9958790] SLC-mediated transport of inorganic anions - Plasmodium falciparum
releaseDate	2025-09-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9962967] D'Eustachio, Peter, 2025-08-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9958790
summation	[Summation:9962925] This pathway serves as collection of reactions categorized a...

Referrals

(hasEvent)	[Pathway:R-HSA-425407] SLC-mediated transmembrane transport
(normalPathway)	[Pathway:R-HSA-5619104] Defective SLC12A1 causes Bartter syndrome 1 (BS1) [Pathway:R-HSA-5619111] Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) [Pathway:R-HSA-5619087] Defective SLC12A3 causes Gitelman syndrome (GS) [Pathway:R-HSA-5619085] Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) [Pathway:R-HSA-5619039] Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) [Pathway:R-HSA-5619045] Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) [Pathway:R-HSA-5619046] Defective SLC26A4 causes Pendred syndrome (PDS) [Pathway:R-HSA-5619040] Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) [Pathway:R-HSA-5619054] Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) [Pathway:R-HSA-5619097] Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) [Pathway:R-HSA-5619096] Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
(replacementInstances)	[Deleted:9960232] Deletion of instance: 425393 [Deleted:9608154] Deletion of instance: 425374

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