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Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
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authored
[InstanceEdit:5619074] Jassal, Bijay, 2014-08-22
created
[InstanceEdit:5619074] Jassal, Bijay, 2014-08-22
crossReference
[DatabaseIdentifier:12819499] BioModels Database:BIOMD0000000327
[DatabaseIdentifier:12021004] Mondo:0001909
[DatabaseIdentifier:12819515] BioModels Database:BIOMD0000000054
dbId
5619054
disease
[Disease:5656215] renal tubular acidosis
displayName
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
edited
[InstanceEdit:5619074] Jassal, Bijay, 2014-08-22
eventOf
[Pathway:R-HSA-5619102] SLC transporter disorders - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[FailedReaction:R-HSA-5656219] Defective SLC4A4 does not cotransport Na+ with 3HCO3- - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2019-03-25
literatureReference
[LiteratureReference:5656239] Proximal renal tubular acidosis mediated by mutations in NBCe1-A: unraveling the transporter's structure-functional properties
[LiteratureReference:5656256] Structure, function, and regulation of the SLC4 NBCe1 transporter and its role in causing proximal renal tubular acidosis
[LiteratureReference:5656201] Molecular mechanisms of renal and extrarenal manifestations caused by inactivation of the electrogenic Na(+)-HCO3 (-) cotransporter NBCe1
[LiteratureReference:5656262] Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities
maxDepth
2
modified
[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
normalPathway
[Pathway:R-HSA-9958790] SLC-mediated transport of inorganic anions
releaseDate
2015-09-22
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:6789776] Broer, Stefan, 2015-08-04
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5619054
summation
[Summation:5656217] Members 4, 5, 7 and 9 of the SLC4A family couple the transpo...
updateTrackers
[UpdateTracker:9777967] Update Tracker - [Pathway:5619054] Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) - v68:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9777967] Update Tracker - [Pathway:5619054] Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) - v68:[updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-5619102] SLC transporter disorders
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