Reactome | CALM binds bacterial OspC3

Schema > Reaction > Entries

authored	[InstanceEdit:9955235] Shamovsky, Veronica, 2025-06-10
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9956599] Shamovsky, Veronica, 2025-06-13
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9956602
disease	[Disease:3134792] bacterial infectious disease
displayName	CALM binds bacterial OspC3
edited	[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
eventOf	[Pathway:R-HSA-9956593] Enterobacterial factors antagonize host defense - Homo sapiens
followingEvent	[Reaction:R-HSA-9956667] CASP4 binds CALM:OspC3 - Homo sapiens
input	[DefinedSet:R-HSA-9958605] CALM [cytosol] [EntityWithAccessionedSequence:R-SFL-9956663] OspC3 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9956594] Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis [LiteratureReference:9956643] Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11
maxDepth	1
modified	[InstanceEdit:9963968] Shamovsky, Veronica, 2025-08-18
name	CALM binds bacterial OspC3
output	[Complex:R-HSA-9956652] CALM:OspC3 [cytosol]
relatedSpecies	[Species:9955275] Shigella flexneri
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9963135] Shi, Xuyan, 2025-08-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9956602
summation	[Summation:9956650] Shigella flexneri, a Gram-negative bacterium that damages th...

(hasEvent)	[Pathway:R-HSA-9956593] Enterobacterial factors antagonize host defense
(precedingEvent)	[Reaction:R-HSA-9956667] CASP4 binds CALM:OspC3

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