Reactome | Enterobacterial factors antagonize host defense

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Enterobacterial factors antagonize host defense Show undefined attributes

authored	[InstanceEdit:9955235] Shamovsky, Veronica, 2025-06-10
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9956599] Shamovsky, Veronica, 2025-06-13
crossReference	[DatabaseIdentifier:12020773] Mondo:0005550
dbId	9956593
disease	[Disease:5663206] disease by infectious agent
displayName	Enterobacterial factors antagonize host defense
doi	10.3180/R-HSA-9956593.2
edited	[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
eventOf	[Pathway:R-HSA-9640148] Infection with Enterobacteria - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9956602] CALM binds bacterial OspC3 - Homo sapiens [Reaction:R-HSA-9956667] CASP4 binds CALM:OspC3 - Homo sapiens [Reaction:R-HSA-9956624] OspC3 ADP-riboxanates CASP4 - Homo sapiens [Reaction:R-HSA-9956613] CASP4 binds nleF - Homo sapiens [Reaction:R-HSA-9955144] S.flexneri ipaH9.8 binds GBPs - Homo sapiens [BlackBoxEvent:R-HSA-9955146] S.flexneri ipaH9.8 ubiquitinates GBPs - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9956664] The E. coli effector protein NleF is a caspase inhibitor [LiteratureReference:9956675] The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection [LiteratureReference:9956594] Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis [LiteratureReference:9956649] Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells
maxDepth	2
modified	[InstanceEdit:9972877] Weiser, Joel, 2025-11-13
name	Enterobacterial factors antagonize host defense
previousReviewStatus	[ReviewStatus:9821384] two stars
relatedSpecies	[Species:9955275] Shigella flexneri [Species:9638490] Escherichia coli O157:H7
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9963135] Shi, Xuyan, 2025-08-12 [InstanceEdit:9970986] Matthews, Lisa, 2025-11-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9956593
summation	[Summation:9956600] This Reactome event describes mechanisms used by intracellul...
updateTrackers	[UpdateTracker:9971925] Update Tracker - [Pathway:9956593] Enterobacterial factors antagonize host defense - v95:[removeHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9971925] Update Tracker - [Pathway:9956593] Enterobacterial factors antagonize host defense - v95:[removeHasEvent]
(hasEvent)	[Pathway:R-HSA-9640148] Infection with Enterobacteria
(hasEncapsulatedEvent)	[Pathway:R-HSA-9686114] Non-canonical inflammasome activation

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