Reactome | LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala

Schema > Reaction > Entries

LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala Show undefined attributes

authored	[InstanceEdit:9948322] May, Bruce, 2025-05-19
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9948292] May, Bruce, 2025-05-19
dbId	9948318
displayName	LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala
edited	[InstanceEdit:9948322] May, Bruce, 2025-05-19
eventOf	[Pathway:R-HSA-9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide - Homo sapiens
followingEvent	[Reaction:R-HSA-9948362] LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide - Homo sapiens [Reaction:R-HSA-9948458] NEMF polymerizes alanine residues onto the C-terminus of the nascent peptide ("CAT tailing") - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5688967] LTN1 [cytosol] [Complex:R-HSA-9948304] NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [cytosol] [EntityWithAccessionedSequence:R-HSA-9948400] TCF25 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9949748] Structure and assembly pathway of the ribosome quality control complex [LiteratureReference:9948379] The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala
orthologousEvent	[Reaction:R-SCE-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Saccharomyces cerevisiae [Reaction:R-SPO-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Schizosaccharomyces pombe [Reaction:R-DDI-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Dictyostelium discoideum [Reaction:R-CEL-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Caenorhabditis elegans [Reaction:R-DME-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Drosophila melanogaster [Reaction:R-GGA-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Gallus gallus [Reaction:R-XTR-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Xenopus tropicalis [Reaction:R-DRE-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Danio rerio [Reaction:R-SSC-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Sus scrofa [Reaction:R-BTA-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Bos taurus [Reaction:R-CFA-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Canis familiaris [Reaction:R-RNO-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Rattus norvegicus [Reaction:R-MMU-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Mus musculus
output	[Complex:R-HSA-9948455] LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [cytosol]
precedingEvent	[Reaction:R-HSA-9948300] RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9962796] Bennett, Eric J, 2025-08-09 [InstanceEdit:9962794] Ford, Pierce W, 2025-08-09 [InstanceEdit:9971505] Jafarnejad, Seyed Mehdi, 2025-11-07 [InstanceEdit:9971510] McGirr, Tom, 2025-11-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9948318
summation	[Summation:9949753] The N-terminal region of Listerin (LTN1), a ubiquitin E3 lig...

Referrals

(hasEvent)	[Pathway:R-HSA-9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
(precedingEvent)	[Reaction:R-HSA-9948362] LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide [Reaction:R-HSA-9948458] NEMF polymerizes alanine residues onto the C-terminus of the nascent peptide ("CAT tailing")

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