Reactome | CHD6 negatively regulates positive strand RNA synthesis

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CHD6 negatively regulates positive strand RNA synthesis Show undefined attributes

authored	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
catalystActivity	[CatalystActivity:192665] RNA-directed RNA polymerase activity of Viral Polymerase [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9944258] Rothfels, Karen, 2025-04-03
crossReference	[DatabaseIdentifier:12020763] Mondo:0005812
dbId	9944257
disease	[Disease:1660558] influenza
displayName	CHD6 negatively regulates positive strand RNA synthesis
edited	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
eventOf	[Pathway:R-HSA-9943962] CHD6, CHD7, CHD8, CHD9 subfamily - Homo sapiens
input	[SimpleEntity:R-ALL-9757634] NTP [nucleoplasm] [Complex:R-FLU-193302] vRNA (Genomic):NP Complex [nucleoplasm]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9944207] PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators [LiteratureReference:9944177] CHD6 chromatin remodeler is a negative modulator of influenza virus replication that relocates to inactive chromatin upon infection [LiteratureReference:9944184] CHD6, a cellular repressor of influenza virus replication, is degraded in human alveolar epithelial cells and mice lungs during infection [LiteratureReference:9816638] At the centre: influenza A virus ribonucleoproteins [LiteratureReference:9944219] Revisiting influenza A virus life cycle from a perspective of genome balance
maxDepth	1
modified	[InstanceEdit:9974210] Rothfels, Karen, 2025-11-20
name	CHD6 negatively regulates positive strand RNA synthesis
output	[Complex:R-FLU-192682] cRNP [nucleoplasm]
regulatedBy	[NegativeGeneExpressionRegulation:9944253] Negative gene expression regulation by 'CHD6:influenza A RNP [nucleoplasm]'
regulationReference	[RegulationReference:9944252] Negative gene expression regulation by 'CHD6:influenza A RNP [nucleoplasm]' CHD6 chromatin remodeler is a negative modulator of influenza virus replication that relocates to inactive chromatin upon infection
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9944257
summation	[Summation:9944277] CHD6 negatively modulates the replication of negative strand...

Referrals

(hasEvent)

[Pathway:R-HSA-9943962] CHD6, CHD7, CHD8, CHD9 subfamily

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