CHD6 negatively regulates positive strand RNA synthesis

Stable Identifier
R-HSA-9944257
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
nucleoplasm
ReviewStatus
3/5
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CHD6 negatively regulates positive strand RNA synthesis
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CHD6 negatively modulates the replication of negative strand viral RNA into positive strand complementary RNA (cRNA) (Huarte et al, 2001; Alfonso et al, 2011; Alfonso et al, 2013). The exact mechanism by which CHD6 has this effect is not clear however there are numerous links between the activity of viral polymerases and the host chromatin environment (reviewed in Du et al, 2023; Eisfeld et al, 2015).
Literature References
PubMed ID Title Journal Year
23408615 CHD6, a cellular repressor of influenza virus replication, is degraded in human alveolar epithelial cells and mice lungs during infection

Alfonso, R, Rodriguez, A, Rodriguez, P, Lutz, T, Nieto, A

J Virol 2013
36309307 Revisiting influenza A virus life cycle from a perspective of genome balance

Du, R, Cui, Q, Chen, Z, Zhao, X, Lin, X, Rong, L

Virol Sin 2023
25417656 At the centre: influenza A virus ribonucleoproteins

Eisfeld, AJ, Neumann, G, Kawaoka, Y

Nat Rev Microbiol 2015
11507205 PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators

Huarte, M, Sanz-Ezquerro, JJ, Roncal, F, Ortín, J, Nieto, A

J Virol 2001
21899694 CHD6 chromatin remodeler is a negative modulator of influenza virus replication that relocates to inactive chromatin upon infection

Alfonso, R, Lutz, T, Rodriguez, A, Chavez, JP, Rodriguez, P, Gutierrez, S, Nieto, A

Cell Microbiol 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

RNA-directed RNA polymerase activity of Viral Polymerase [nucleoplasm]

Physical Entity
Viral Polymerase [nucleoplasm] (Influenza A virus)
Activity
RNA-directed RNA polymerase activity (GO:0003968)
This event is regulated
Negatively by
Regulator
CHD6:influenza A RNP [nucleoplasm] (Homo sapiens)
Active Unit
CHD6 [nucleoplasm]
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Cross References
Mondo
Authored
Rothfels, K  (2025-02-07)
Created
Rothfels, K  (2025-04-03)
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