Reactome | NuRD hydrolyzes ATP to affect nucleosome organization

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NuRD hydrolyzes ATP to affect nucleosome organization Show undefined attributes

authored	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
catalystActivity	[CatalystActivity:9944082] ATP hydrolysis activity of NuRD [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9944094] Rothfels, Karen, 2025-04-02
crossReference	[DatabaseIdentifier:9944085] RHEA:13065
dbId	9944091
displayName	NuRD hydrolyzes ATP to affect nucleosome organization
edited	[InstanceEdit:9937860] Rothfels, Karen, 2025-02-07
eventOf	[Pathway:R-HSA-9937850] NuRD complex assembly - Homo sapiens
followingEvent	[Reaction:R-HSA-9944092] NuRD deacetylates nucleosomes - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-9944076] chromatin with acetylated nucleosome [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9937777] Histone deacetylase complexes: Structure, regulation and function [LiteratureReference:9938062] Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease [LiteratureReference:9938283] Class I HDACs share a common mechanism of regulation by inositol phosphates [LiteratureReference:9944063] Distinct activities of CHD1 and ACF in ATP-dependent chromatin assembly [LiteratureReference:9943382] Human CHD2 is a chromatin assembly ATPase regulated by its chromo- and DNA-binding domains [LiteratureReference:9937757] CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality [LiteratureReference:9944060] The tumor suppressor chromodomain helicase DNA-binding protein 5 (CHD5) remodels nucleosomes by unwrapping [LiteratureReference:9943900] The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities [LiteratureReference:9933295] Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes [LiteratureReference:5228892] NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities [LiteratureReference:9938010] Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex [LiteratureReference:3662305] Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase
maxDepth	1
modified	[InstanceEdit:9974212] Rothfels, Karen, 2025-11-20
name	NuRD hydrolyzes ATP to affect nucleosome organization
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-9944076] chromatin with acetylated nucleosome [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9940468] CHD and CDK2AP subunits are recruited to NuRD - Homo sapiens
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9944091
summation	[Summation:9944057] This reaction shows a generic representation of the histone ...

Referrals

(hasEvent)	[Pathway:R-HSA-9937850] NuRD complex assembly
(precedingEvent)	[Reaction:R-HSA-9944092] NuRD deacetylates nucleosomes