Reactome | MTPAP polyadenylates mitochondrial mRNA

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MTPAP polyadenylates mitochondrial mRNA Show undefined attributes

authored	[InstanceEdit:9936974] May, Bruce, 2025-01-25
catalystActivity	[CatalystActivity:9936964] poly(A) RNA polymerase activity of MTPAP:Mg2+ dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9936995] May, Bruce, 2025-01-28
dbId	9936998
displayName	MTPAP polyadenylates mitochondrial mRNA
edited	[InstanceEdit:9936974] May, Bruce, 2025-01-25
eventOf	[Pathway:R-HSA-9937008] Mitochondrial mRNA modification - Homo sapiens
input	40 × [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [DefinedSet:R-HSA-9936931] Mitochondrial mRNA [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9937014] Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase [LiteratureReference:9936937] Stable PNPase RNAi silencing: its effect on the processing and adenylation of human mitochondrial RNA [LiteratureReference:9936938] Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase [LiteratureReference:9937010] A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression
maxDepth	1
modified	[InstanceEdit:9949648] May, Bruce, 2025-05-23
name	MTPAP polyadenylates mitochondrial mRNA
output	[DefinedSet:R-HSA-9936987] Polyadenylated mitochondrial mRNA [mitochondrial matrix] 40 × [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:R-HSA-6785722] Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript - Homo sapiens [BlackBoxEvent:R-HSA-6786854] Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript - Homo sapiens
regulatedBy	[PositiveRegulation:9936933] Positive regulation by 'SLIRP:LRPPRC [mitochondrial matrix]'
regulationReference	[RegulationReference:9936985] Positive regulation by 'SLIRP:LRPPRC [mitochondrial matrix]' A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9936998
summation	[Summation:9937018] MTPAP (PAPD1) polymerizes relatively short polyadenylate tai...

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(hasEvent)

[Pathway:R-HSA-9937008] Mitochondrial mRNA modification