Reactome | NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome

Schema > Reaction > Entries

NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome Show undefined attributes

authored	[InstanceEdit:9935059] May, Bruce, 2025-01-12
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9935313] May, Bruce, 2025-01-14
dbId	9935282
displayName	NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome
edited	[InstanceEdit:9935059] May, Bruce, 2025-01-12
eventOf	[Pathway:R-HSA-9930044] Nuclear RNA decay - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9935290] The RNA exosome in RNA exosome:NEXT:ZC3H4:WDR82:CBCA:capped RNA hydrolyzes capped RNA - Homo sapiens
input	[Complex:R-HSA-9930060] NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] [Complex:R-HSA-9933578] RNA exosome [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9934084] ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts [LiteratureReference:9934095] A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription [LiteratureReference:9934516] The human cap-binding complex is functionally connected to the nuclear RNA exosome [LiteratureReference:6791506] C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome
orthologousEvent	[Reaction:R-CEL-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Caenorhabditis elegans [Reaction:R-DME-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Drosophila melanogaster [Reaction:R-GGA-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Gallus gallus [Reaction:R-XTR-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Xenopus tropicalis [Reaction:R-DRE-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Danio rerio [Reaction:R-SSC-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Sus scrofa [Reaction:R-BTA-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Bos taurus [Reaction:R-CFA-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Canis familiaris [Reaction:R-RNO-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Rattus norvegicus [Reaction:R-MMU-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Mus musculus
output	[Complex:R-HSA-9935306] RNA exosome:NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9969603] Tong, Liang, 2025-10-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9935282
summation	[Summation:9935636] The EXOSC10 (RRP6, PM/Scl-100) subunit of the RNA exosome in...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9935290] The RNA exosome in RNA exosome:NEXT:ZC3H4:WDR82:CBCA:capped RNA hydrolyzes capped RNA
(hasEvent)	[Pathway:R-HSA-9930044] Nuclear RNA decay