Reactome | The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA

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The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA Show undefined attributes

authored	[InstanceEdit:9930042] May, Bruce, 2024-11-30
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9930061] May, Bruce, 2024-12-01
dbId	9930059
displayName	The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA
edited	[InstanceEdit:9930042] May, Bruce, 2024-11-30
eventOf	[Pathway:R-HSA-9930044] Nuclear RNA decay - Homo sapiens
followingEvent	[Reaction:R-HSA-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome - Homo sapiens
input	[Complex:R-HSA-9935998] NEXT homodimer [nucleoplasm] [Complex:R-HSA-9935256] ZC3H4:WDR82:CBCA:m7GpppN-RNA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9934084] ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts [LiteratureReference:9934095] A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription [LiteratureReference:9935271] A first exon termination checkpoint preferentially suppresses extragenic transcription [LiteratureReference:9935316] ZC3H4 restricts non-coding transcription in human cells [LiteratureReference:9934515] The human nuclear exosome targeting complex is loaded onto newly synthesized RNA to direct early ribonucleolysis [LiteratureReference:9934093] A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome [LiteratureReference:9935991] Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex [LiteratureReference:9936001] Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA
orthologousEvent	[Reaction:R-CEL-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Caenorhabditis elegans [Reaction:R-DME-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Drosophila melanogaster [Reaction:R-GGA-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Gallus gallus [Reaction:R-XTR-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Xenopus tropicalis [Reaction:R-DRE-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Danio rerio [Reaction:R-SSC-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Sus scrofa [Reaction:R-BTA-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Bos taurus [Reaction:R-CFA-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Canis familiaris [Reaction:R-RNO-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Rattus norvegicus [Reaction:R-MMU-9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA - Mus musculus
output	[Complex:R-HSA-9930060] NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9821474] WDR82 [nucleoplasm]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9969603] Tong, Liang, 2025-10-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9930059
summation	[Summation:9935258] The ZC3H4:WDR82 complex (Austenaa et al. 2021, Estell et al....

Referrals

(hasEvent)	[Pathway:R-HSA-9930044] Nuclear RNA decay
(precedingEvent)	[Reaction:R-HSA-9935282] NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome

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