Reactome | ADAMTS13 cleaves VWF multimer bound to FVIII

Schema > BlackBoxEvent > Entries

ADAMTS13 cleaves VWF multimer bound to FVIII Show undefined attributes

authored	[InstanceEdit:9934617] Shamovsky, Veronica, 2025-01-09
catalystActivity	[CatalystActivity:9822533] metalloendopeptidase activity of glc-fuc-ADAMTS13 [extracellular region]
catalystActivityReference	[CatalystActivityReference:9934627] metalloendopeptidase activity of glc-fuc-ADAMTS13 [extracellular region] Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress
category	omitted
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9934617] Shamovsky, Veronica, 2025-01-09
dbId	9934645
displayName	ADAMTS13 cleaves VWF multimer bound to FVIII
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
eventOf	[Pathway:R-HSA-9769739] Regulation of clotting cascade - Homo sapiens
input	[Complex:R-HSA-158363] factor VIII:von Willebrand factor multimer [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9934648] Factor VIII binding affects the mechanical unraveling of the A2 domain of von Willebrand factor [LiteratureReference:9934644] Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress [LiteratureReference:9934625] Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13 [LiteratureReference:9934621] Coagulation factor VIII regulates von Willebrand factor homeostasis invivo [LiteratureReference:9824136] Crystal structure and substrate-induced activation of ADAMTS13 [LiteratureReference:9824127] Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor [LiteratureReference:9824134] Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis [LiteratureReference:9824337] A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von Willebrand factor [LiteratureReference:9822803] Force-sensitive autoinhibition of the von Willebrand factor is mediated by interdomain interactions
maxDepth	1
modified	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
name	ADAMTS13 cleaves VWF multimer bound to FVIII
orthologousEvent	[BlackBoxEvent:R-BTA-9934645] ADAMTS13 cleaves VWF multimer bound to FVIII - Bos taurus [BlackBoxEvent:R-MMU-9934645] ADAMTS13 cleaves VWF multimer bound to FVIII - Mus musculus
output	[Complex:R-HSA-9934635] FVIII:cleaved VWF multimer [extracellular region]
precedingEvent	[Reaction:R-HSA-9822539] VWF multimer binds to collagen type I - Homo sapiens
releaseDate	2026-03-25
releaseStatus	NEW
requiredInputComponent	[SimpleEntity:R-ALL-158417] Zn2+ [extracellular region]
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9934645
summation	[Summation:9934637] In circulation, von Willebrand factor (VWF) multimers detect...

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[Pathway:R-HSA-9769739] Regulation of clotting cascade