Reactome | factor VIII:von Willebrand factor multimer [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
consumedByEvent	[BlackBoxEvent:R-HSA-9934645] ADAMTS13 cleaves VWF multimer bound to FVIII - Homo sapiens [Reaction:R-HSA-9822522] factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst) - Homo sapiens [Reaction:R-HSA-158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer - Homo sapiens
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
dbId	158363
displayName	factor VIII:von Willebrand factor multimer [extracellular region]
hasComponent	[Complex:R-HSA-158350] factor VIII [extracellular region] 50 × [EntityWithAccessionedSequence:R-HSA-158327] VWF(764-2813) [extracellular region]
inDisease	false
inferredTo	[Complex:R-MMU-158363] factor VIII:von Willebrand factor multimer [extracellular region] - Mus musculus [Complex:R-BTA-158363] factor VIII:von Willebrand factor multimer [extracellular region] - Bos taurus
maxDepth	3
modified	[InstanceEdit:158648] D'Eustachio, P, 2005-02-03 20:04:19
name	factor VIII:von Willebrand factor multimer
producedByEvent	[Reaction:R-HSA-158118] factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-158363

(normalEntity)	[EntityFunctionalStatus:9666390] loss_of_function of FVIII variant:vWF multimer [extracellular region]
(input)	[BlackBoxEvent:R-HSA-9934645] ADAMTS13 cleaves VWF multimer bound to FVIII [Reaction:R-HSA-9822522] factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst) [Reaction:R-HSA-158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer
(output)	[Reaction:R-HSA-158118] factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer