Reactome | BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2

Schema > Reaction > Entries

BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 Show undefined attributes

authored	[InstanceEdit:9934146] Rothfels, Karen, 2025-01-06
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9932831] Rothfels, Karen, 2024-12-20
dbId	9932832
displayName	BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2
edited	[InstanceEdit:9934146] Rothfels, Karen, 2025-01-06
eventOf	[Pathway:R-HSA-9933939] Formation of the polybromo-BAF (pBAF) complex - Homo sapiens
followingEvent	[Reaction:R-HSA-9932843] PHF10 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD7 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3222092] BRD7 [nucleoplasm] [Complex:R-HSA-9932418] SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9933883] BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells [LiteratureReference:9932366] A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms [LiteratureReference:9727476] Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes [LiteratureReference:9932752] Structure of nucleosome-bound human PBAF complex [LiteratureReference:9932803] Structure of human chromatin-remodelling PBAF complex bound to a nucleosome [LiteratureReference:9932772] A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation [LiteratureReference:9932813] The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain [LiteratureReference:9932779] Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4 [LiteratureReference:8865597] Histone recognition and large-scale structural analysis of the human bromodomain family [LiteratureReference:9932770] A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2
orthologousEvent	[Reaction:R-CEL-9932832] BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 - Caenorhabditis elegans [Reaction:R-DME-9932832] BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 - Drosophila melanogaster [Reaction:R-GGA-9932832] BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 - Gallus gallus [Reaction:R-SSC-9932832] BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 - Sus scrofa [Reaction:R-BTA-9932832] BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 - Bos taurus [Reaction:R-CFA-9932832] BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 - Canis familiaris [Reaction:R-RNO-9932832] BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 - Rattus norvegicus [Reaction:R-MMU-9932832] BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 - Mus musculus
output	[Complex:R-HSA-9932833] SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD7 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9932440] ARID2 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938992] Dykhuizen, Emily C, 2025-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9932832
summation	[Summation:9932819] BRD7 is a pBAF-specific component (Kaeser et al, 2008; Masht...

Referrals

(hasEvent)	[Pathway:R-HSA-9933939] Formation of the polybromo-BAF (pBAF) complex
(precedingEvent)	[Reaction:R-HSA-9932843] PHF10 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD7

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