Reactome | POLG in the replisome polymerizes the H strand

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POLG in the replisome polymerizes the H strand Show undefined attributes

authored	[InstanceEdit:9914490] May, Bruce, 2024-06-17
catalystActivity	[CatalystActivity:9914492] DNA-directed DNA polymerase activity of Mitochondrial H strand replisome with unwound replication fork [mitochondrial matrix]
category	omitted
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9914421] May, Bruce, 2024-06-24
dbId	9914364
displayName	POLG in the replisome polymerizes the H strand
edited	[InstanceEdit:9914490] May, Bruce, 2024-06-17
eventOf	[Pathway:R-HSA-9913635] Strand-asynchronous mitochondrial DNA replication - Homo sapiens
followingEvent	[Reaction:R-HSA-9914478] SSBP1 binds the displaced parental H strand - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17102] mitochondrial DNA replication
input	[SimpleEntity:R-ALL-110653] dATP [mitochondrial matrix] [SimpleEntity:R-ALL-110669] dCTP [mitochondrial matrix] [SimpleEntity:R-ALL-110681] dGTP [mitochondrial matrix] [SimpleEntity:R-ALL-110719] dTTP [mitochondrial matrix] [Complex:R-HSA-9914461] Mitochondrial H strand replisome with unwound replication fork [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9914472] Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro [LiteratureReference:9913629] Reconstitution of a minimal mtDNA replisome in vitro [LiteratureReference:9914987] Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB [LiteratureReference:9914993] A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase [LiteratureReference:9915737] The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance [LiteratureReference:9915747] Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization [LiteratureReference:9915723] Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations [LiteratureReference:9915739] Structure-specific roles for PolG2-DNA complexes in maintenance and replication of mitochondrial DNA
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	POLG in the replisome polymerizes the H strand
orthologousEvent	[BlackBoxEvent:R-DME-9914364] POLG in the replisome polymerizes the H strand - Drosophila melanogaster [BlackBoxEvent:R-GGA-9914364] POLG in the replisome polymerizes the H strand - Gallus gallus [BlackBoxEvent:R-XTR-9914364] POLG in the replisome polymerizes the H strand - Xenopus tropicalis [BlackBoxEvent:R-DRE-9914364] POLG in the replisome polymerizes the H strand - Danio rerio [BlackBoxEvent:R-SSC-9914364] POLG in the replisome polymerizes the H strand - Sus scrofa [BlackBoxEvent:R-BTA-9914364] POLG in the replisome polymerizes the H strand - Bos taurus [BlackBoxEvent:R-CFA-9914364] POLG in the replisome polymerizes the H strand - Canis familiaris [BlackBoxEvent:R-RNO-9914364] POLG in the replisome polymerizes the H strand - Rattus norvegicus [BlackBoxEvent:R-MMU-9914364] POLG in the replisome polymerizes the H strand - Mus musculus
output	[Complex:R-HSA-9914429] Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9914438] TWNK (PEO1) unwinds double-stranded mitochondrial DNA at the replication fork - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9925848] Wu, Chyuan-Chuan, 2024-10-27
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9914364
summation	[Summation:9915741] The POLG subunit of mitochondrial DNA polymerase gamma (POLg...

Referrals

(hasEvent)	[Pathway:R-HSA-9913635] Strand-asynchronous mitochondrial DNA replication
(precedingEvent)	[Reaction:R-HSA-9914478] SSBP1 binds the displaced parental H strand

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