Reactome | POLG in the replisome polymerizes the H strand

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POLG in the replisome polymerizes the H strand Show undefined attributes

catalystActivity	[CatalystActivity:10645734] DNA-directed DNA polymerase activity of Mitochondrial H strand replisome with unwound replication fork [mitochondrial matrix]
category	omitted
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10645736
displayName	POLG in the replisome polymerizes the H strand
eventOf	[Pathway:R-DRE-9913635] Strand-asynchronous mitochondrial DNA replication - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-9914478] SSBP1 binds the displaced parental H strand - Danio rerio
goBiologicalProcess	[GO_BiologicalProcess:17102] mitochondrial DNA replication
inferredFrom	[BlackBoxEvent:R-HSA-9914364] POLG in the replisome polymerizes the H strand - Homo sapiens
input	[SimpleEntity:R-ALL-110653] dATP [mitochondrial matrix] [SimpleEntity:R-ALL-110669] dCTP [mitochondrial matrix] [SimpleEntity:R-ALL-110681] dGTP [mitochondrial matrix] [SimpleEntity:R-ALL-110719] dTTP [mitochondrial matrix] [Complex:R-DRE-9914461] Mitochondrial H strand replisome with unwound replication fork [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	POLG in the replisome polymerizes the H strand
output	[Complex:R-DRE-9914429] Mitochondrial H strand replisome:H strand RNA primer:nascent H strand DNA [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent	[Reaction:R-DRE-9914438] TWNK (PEO1) unwinds double-stranded mitochondrial DNA at the replication fork - Danio rerio
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68323] Danio rerio
stId	R-DRE-9914364
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9913635] Strand-asynchronous mitochondrial DNA replication
(precedingEvent)	[Reaction:R-DRE-9914478] SSBP1 binds the displaced parental H strand
(inferredTo)	[BlackBoxEvent:R-HSA-9914364] POLG in the replisome polymerizes the H strand