Reactome | MdtE:MdtF:TolC exports beta-lactams to the periplasm

Schema > Reaction > Entries

MdtE:MdtF:TolC exports beta-lactams to the periplasm Show undefined attributes

authored	[InstanceEdit:9914081] Stephan, Ralf, 2024-06-20
catalystActivity	[CatalystActivity:9914080] xenobiotic transmembrane transporter activity of MdtE:MdtF:TolC [cell outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:1222638] periplasmic space [Compartment:876] plasma membrane
created	[InstanceEdit:9914076] Stephan, Ralf, 2024-06-20
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9914089
disease	[Disease:3134792] bacterial infectious disease
displayName	MdtE:MdtF:TolC exports beta-lactams to the periplasm
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9913143] Antimicrobial resistance - Homo sapiens
followingEvent	[Reaction:R-HSA-9914083] MdtE:MdtF:TolC exports beta-lactams to extracellular space - Homo sapiens [Reaction:R-HSA-9911516] AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-8858135] H+ [periplasmic space] [DefinedSet:R-ALL-9638903] ?-lactam antibiotics [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9914074] Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams [LiteratureReference:9639435] AcrA is a highly asymmetric protein capable of spanning the periplasm [LiteratureReference:9911303] RND transporters in the living world [LiteratureReference:9911195] Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria
maxDepth	1
modified	[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	MdtE:MdtF:TolC exports beta-lactams to the periplasm
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [DefinedSet:R-ALL-9913950] ?-lactam antibiotics [periplasmic space]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9914089
summation	[Summation:9914088] The MdtE/MdtF (aka MdtEF or YhiUV) transporter complex in th...

Referrals

(hasEvent)	[Pathway:R-HSA-9913143] Antimicrobial resistance
(precedingEvent)	[Reaction:R-HSA-9914083] MdtE:MdtF:TolC exports beta-lactams to extracellular space [Reaction:R-HSA-9911516] AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region

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