Reactome | Pef exports fluoroquinolones

Schema > Reaction > Entries

Pef exports fluoroquinolones Show undefined attributes

authored	[InstanceEdit:9913427] Stephan, Ralf, 2024-06-14
catalystActivity	[CatalystActivity:9913432] xenobiotic transmembrane transporter activity of Pef [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:1222638] periplasmic space
created	[InstanceEdit:9913448] Stephan, Ralf, 2024-06-14
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9913437
disease	[Disease:3134792] bacterial infectious disease
displayName	Pef exports fluoroquinolones
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9913143] Antimicrobial resistance - Homo sapiens
followingEvent	[Reaction:R-HSA-9911516] AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region - Homo sapiens
input	[DefinedSet:R-ALL-9912557] Fluoroquinolone antibiotics [cytosol] [SimpleEntity:R-ALL-8858135] H+ [periplasmic space]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9913140] The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic [LiteratureReference:9913434] Transferable mechanisms of quinolone resistance [LiteratureReference:9913450] New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate [LiteratureReference:9913439] Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli
maxDepth	1
modified	[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	Pef exports fluoroquinolones
output	[DefinedSet:R-ALL-9913444] Fluoroquinolone antibiotics [periplasmic space] [SimpleEntity:R-ALL-70106] H+ [cytosol]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9913437
summation	[Summation:9913433] pef (aka qepA)-like genes, coding for transport proteins of ...

Referrals

(precedingEvent)	[Reaction:R-HSA-9911516] AcrA:AcrB:TolC transports antibiotics from the periplasm to the extracellular region
(hasEvent)	[Pathway:R-HSA-9913143] Antimicrobial resistance

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