Reactome | Fluoroquinolones bind gyrase

Schema > Reaction > Entries

authored	[InstanceEdit:9913149] Stephan, Ralf, 2024-06-12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9913145] Stephan, Ralf, 2024-06-12
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9913142
disease	[Disease:3134792] bacterial infectious disease
displayName	Fluoroquinolones bind gyrase
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9638771] Action of antimicrobials - Homo sapiens
input	[DefinedSet:R-ALL-9912557] Fluoroquinolone antibiotics [cytosol] [Complex:R-ECO-9639502] gyrase [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9913140] The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic [LiteratureReference:9913434] Transferable mechanisms of quinolone resistance
maxDepth	1
modified	[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	Fluoroquinolones bind gyrase
output	[Complex:R-ECO-9913146] Fluoroquinolones:gyrase [cytosol]
regulatedBy	[NegativeRegulation:9913153] Negative regulation by 'Qnr:gyrase [cytosol]' [NegativeRegulation:9913440] Negative regulation by 'N-acetylciprofloxacin [cytosol]'
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9913142
summation	[Summation:9913147] The main bactericidal effect of fluoroquinolone antibiotics ...

(hasEvent)

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