Reactome | MacA:MacB:TolC transports azithromycin from the cytosol to the periplasm

Schema > Reaction > Entries

MacA:MacB:TolC transports azithromycin from the cytosol to the periplasm Show undefined attributes

authored	[InstanceEdit:9638337] Stephan, Ralf, 2019-02-21
catalystActivity	[CatalystActivity:9911301] ABC-type xenobiotic transporter activity of MacA:MacB:TolC [cell outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:1222638] periplasmic space
created	[InstanceEdit:9911521] Stephan, Ralf, 2024-06-01
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9911514
deleted	[Deleted:9911540] Deletion of instance: 9639466
disease	[Disease:3134792] bacterial infectious disease
displayName	MacA:MacB:TolC transports azithromycin from the cytosol to the periplasm
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9913143] Antimicrobial resistance - Homo sapiens
followingEvent	[Reaction:R-HSA-9911510] MacA:MacB:TolC transports azithromycin from the periplasm to the extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [ChemicalDrug:R-ALL-39493] azithromycin [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9639429] Novel macrolide-specific ABC-type efflux transporter in Escherichia coli [LiteratureReference:9911186] Structures of sequential open states in a symmetrical opening transition of the TolC exit duct [LiteratureReference:9911195] Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria
maxDepth	1
modified	[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	MacA:MacB:TolC transports azithromycin from the cytosol to the periplasm
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [ChemicalDrug:R-ALL-9911188] azithromycin [periplasmic space] [SimpleEntity:R-ALL-29372] Pi [cytosol]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9911514
summation	[Summation:9639479] The tripartite efflux system MacA:MacB:TolC in enterobacteri...

Referrals

(replacementInstances)	[Deleted:9911540] Deletion of instance: 9639466
(hasEvent)	[Pathway:R-HSA-9913143] Antimicrobial resistance
(precedingEvent)	[Reaction:R-HSA-9911510] MacA:MacB:TolC transports azithromycin from the periplasm to the extracellular region

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