Reactome | STAT3 dimer binding to CD274 gene

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STAT3 dimer binding to CD274 gene Show undefined attributes

authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927358] Tiwari, Krishna, 2024-11-05
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9909599] Tiwari, Krishna, 2024-05-14
dbId	9909609
displayName	STAT3 dimer binding to CD274 gene
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
eventOf	[Pathway:R-HSA-9909649] Regulation of PD-L1(CD274) transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9909623] CD274 Transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9701419] CD274 gene [nucleoplasm] [CandidateSet:R-HSA-9909603] STAT3 dimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9701294] Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1) [LiteratureReference:9912240] Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma [LiteratureReference:9912192] ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma
maxDepth	1
modified	[InstanceEdit:9965199] Matthews, Lisa, 2025-08-26
name	STAT3 dimer binding to CD274 gene
output	[Complex:R-HSA-9909600] STAT3_dimer:CD274 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-6784763] p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9909609
summation	[Summation:9912251] STAT3 (Signal Transducer and Activator of Transcription 3) r...

Referrals

(hasEvent)	[Pathway:R-HSA-9909649] Regulation of PD-L1(CD274) transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-9909623] CD274 Transcription

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