STAT3 dimer binding to CD274 gene

Stable Identifier
R-HSA-9909609
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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STAT3 dimer binding to CD274 gene
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STAT3 (Signal Transducer and Activator of Transcription 3) regulates CD274 (PD-L1) transcription in response to various cytokines and growth factors, including IL-6. Upon activation, STAT3 becomes phosphorylated, dimerizes, and translocates to the nucleus, where it binds to specific STAT3-responsive elements in the PD-L1 promoter region. This binding recruits transcriptional co-activators and the transcriptional machinery, leading to increased PD-L1 gene transcription (Marzec et al., 2008, Song et al., 2018, Tong et al., 2020).
Literature References
PubMed ID Title Journal Year
19088198 Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

Marzec, M, Zhang, Q, Goradia, A, Raghunath, PN, Liu, X, Paessler, M, Wang, HY, Wysocka, M, Cheng, M, Ruggeri, BA, Wasik, MA

Proc. Natl. Acad. Sci. U.S.A. 2008
32483429 ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma

Tong, L, Li, J, Li, Q, Wang, X, Medikonda, R, Zhao, T, Li, T, Ma, H, Yi, L, Liu, P, Xie, Y, Choi, J, Yu, S, Lin, Y, Dong, J, Huang, Q, Jin, X, Lim, M, Yang, X

Theranostics 2020
30054295 Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

Song, TL, Nairismägi, ML, Laurensia, Y, Lim, JQ, Tan, J, Li, ZM, Pang, WL, Kizhakeyil, A, Wijaya, GC, Huang, DC, Nagarajan, S, Chia, BK, Cheah, D, Liu, YH, Zhang, F, Rao, HL, Tang, T, Wong, EK, Bei, JX, Iqbal, J, Grigoropoulos, NF, Ng, SB, Chng, WJ, Teh, BT, Tan, SY, Verma, NK, Fan, H, Lim, ST, Ong, CK

Blood 2018
Participants
Input
Output
Participates
as an event of
Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2024-05-14)
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