Reactome | kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst)

Schema > Reaction > Entries

kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) Show undefined attributes

authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
catalystActivity	[CatalystActivity:9909043] serine-type endopeptidase activity of kallikrein:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9857821] serine-type endopeptidase activity of FXII:C1QBP,C1QBP:KRT1, PLAUR:KRT1 [plasma membrane] Factor XII-dependent contact activation on endothelial cells and binding proteins gC1qR and cytokeratin 1
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9909044] Shamovsky, Veronica, 2024-04-25
dbId	9909046
displayName	kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst)
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
eventOf	[Pathway:R-HSA-9970672] FXIIa activates plasma kallikrein-kinin system - Homo sapiens
followingEvent	[Reaction:R-HSA-9938539] kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin - Homo sapiens [Reaction:R-HSA-9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) - Homo sapiens [Reaction:R-HSA-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Homo sapiens
input	[Complex:R-HSA-9909047] kallikrein:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9857949] Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery [LiteratureReference:9855707] Single-chain factor XII exhibits activity when complexed to polyphosphate [LiteratureReference:158256] Factor XII interacts with the multiprotein assembly of urokinase plasminogen activator receptor, gC1qR, and cytokeratin 1 on endothelial cell membranes [LiteratureReference:158349] Factor XII-dependent contact activation on endothelial cells and binding proteins gC1qR and cytokeratin 1 [LiteratureReference:158281] Activation and function of human Hageman factor. The role of high molecular weight kininogen and prekallikrein. [LiteratureReference:158249] The physiologic basis of assembly and activation of the plasma kallikrein/kinin system
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) kallikrein:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII -> FXIIa + kallikrein:KNG1:(C1QBP, C1QBP:KRT1, PLAUR:KRT1)
orthologousEvent	[Reaction:R-BTA-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) - Bos taurus [Reaction:R-GGA-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) - Gallus gallus [Reaction:R-XTR-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) - Xenopus tropicalis [Reaction:R-SSC-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) - Sus scrofa [Reaction:R-RNO-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) - Rattus norvegicus [Reaction:R-MMU-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) - Mus musculus
output	[Complex:R-HSA-158306] factor XIIa [extracellular region] [Complex:R-HSA-9909045] kallikrein:KNG1:C1QBP, C1QBP:KRT1, PLAUR:KRT1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9909048] prekallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor:factor XII (FXII catalyst) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9909046
summation	[Summation:9938545] Binding of factor XII (FXII) to cell surface receptors facil...

Referrals

(precedingEvent)

[Reaction:R-HSA-9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst)
[Reaction:R-HSA-9938539] kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin
[Reaction:R-HSA-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)

(hasEvent)

[Pathway:R-HSA-9970672] FXIIa activates plasma kallikrein-kinin system