Reactome | kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst)

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kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10440383] serine-type endopeptidase activity of kallikrein:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10440385
displayName	kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst)
eventOf	[Pathway:R-BTA-9970672] FXIIa activates plasma kallikrein-kinin system - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9938539] kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin - Bos taurus [Reaction:R-BTA-9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) - Bos taurus [Reaction:R-BTA-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Bos taurus
inferredFrom	[Reaction:R-HSA-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) - Homo sapiens
input	[Complex:R-BTA-9909047] kallikrein:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) kallikrein:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII -> FXIIa + kallikrein:KNG1:(C1QBP, C1QBP:KRT1, PLAUR:KRT1)
output	[Complex:R-BTA-158306] factor XIIa [extracellular region] [Complex:R-BTA-9909045] kallikrein:KNG1:C1QBP, C1QBP:KRT1, PLAUR:KRT1 [plasma membrane]
precedingEvent	[Reaction:R-BTA-9909048] prekallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor:factor XII (FXII catalyst) - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9909046
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-BTA-9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) [Reaction:R-BTA-9938539] kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin [Reaction:R-BTA-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
(hasEvent)	[Pathway:R-BTA-9970672] FXIIa activates plasma kallikrein-kinin system
(inferredTo)	[Reaction:R-HSA-9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst)

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