Reactome | TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+)

Schema > Reaction > Entries

TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) Show undefined attributes

authored	[InstanceEdit:9865661] May, Bruce, 2024-03-16
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9865672] May, Bruce, 2024-03-17
dbId	9865670
displayName	TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+)
edited	[InstanceEdit:9865661] May, Bruce, 2024-03-16
eventOf	[Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Homo sapiens
followingEvent	[Reaction:R-HSA-9858800] TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol - Homo sapiens
input	4 × [Complex:R-HSA-74294] CALM1:4xCa2+ [cytosol] [Complex:R-HSA-9858825] TRPV4 tetramer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9863414] Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site [LiteratureReference:9865675] Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+)
orthologousEvent	[Reaction:R-CEL-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) - Caenorhabditis elegans [Reaction:R-DME-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) - Drosophila melanogaster [Reaction:R-BTA-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) - Bos taurus [Reaction:R-CFA-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) - Canis familiaris [Reaction:R-RNO-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) - Rattus norvegicus [Reaction:R-MMU-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) - Mus musculus
output	[Complex:R-HSA-9865674] TRPV4 tetramer:CALM1:Ca2+ [plasma membrane]
precedingEvent	[Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens
releaseDate	2024-09-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9865670
summation	[Summation:9865673] Calmodulin (CALM1) in a complex with Ca2+ binds a domain in ...

Referrals

(hasEvent)	[Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
(precedingEvent)	[Reaction:R-HSA-9858800] TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol