Reactome | PGAM5 dodecamer dephosphorylates p-S336-ME1

Schema > Reaction > Entries

PGAM5 dodecamer dephosphorylates p-S336-ME1 Show undefined attributes

authored	[InstanceEdit:9861713] Stephan, Ralf, 2024-01-25
catalystActivity	[CatalystActivity:9861707] protein serine/threonine phosphatase activity of PGAM5 dodecamer [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9861650] Stephan, Ralf, 2024-02-21
crossReference	[DatabaseIdentifier:9857130] RHEA:20630
dbId	9861725
displayName	PGAM5 dodecamer dephosphorylates p-S336-ME1
edited	[InstanceEdit:9862190] Stephan, Ralf, 2024-02-23
eventOf	[Pathway:R-HSA-9861718] Regulation of pyruvate metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9861631] ME1 tetramerizes - Homo sapiens [Reaction:R-HSA-9861642] NEK1 phosphorylates ME1 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-HSA-9861606] p-S336-ME1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9861574] Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis [LiteratureReference:9861637] Functional role of PGAM5 multimeric assemblies and their polymerization into filaments [LiteratureReference:9861571] PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PGAM5 dodecamer dephosphorylates p-S336-ME1
orthologousEvent	[Reaction:R-CEL-9861725] PGAM5 dodecamer dephosphorylates p-S336-ME1 - Caenorhabditis elegans [Reaction:R-DME-9861725] PGAM5 dodecamer dephosphorylates p-S336-ME1 - Drosophila melanogaster [Reaction:R-DRE-9861725] PGAM5 dodecamer dephosphorylates p-S336-ME1 - Danio rerio [Reaction:R-GGA-9861725] PGAM5 dodecamer dephosphorylates p-S336-ME1 - Gallus gallus [Reaction:R-SSC-9861725] PGAM5 dodecamer dephosphorylates p-S336-ME1 - Sus scrofa [Reaction:R-BTA-9861725] PGAM5 dodecamer dephosphorylates p-S336-ME1 - Bos taurus [Reaction:R-CFA-9861725] PGAM5 dodecamer dephosphorylates p-S336-ME1 - Canis familiaris [Reaction:R-RNO-9861725] PGAM5 dodecamer dephosphorylates p-S336-ME1 - Rattus norvegicus [Reaction:R-MMU-9861725] PGAM5 dodecamer dephosphorylates p-S336-ME1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-400119] ME1 [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-9861642] NEK1 phosphorylates ME1 - Homo sapiens
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9862191] Hill, David P, 2024-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9861725
summation	[Summation:9861577] Serine/threonine-protein phosphatase PGAM5 (aka phosphoglyce...

Referrals

(hasEvent)	[Pathway:R-HSA-9861718] Regulation of pyruvate metabolism
(precedingEvent)	[Reaction:R-HSA-9861631] ME1 tetramerizes [Reaction:R-HSA-9861642] NEK1 phosphorylates ME1