Reactome | Response of endothelial cells to shear stress

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Response of endothelial cells to shear stress Show undefined attributes

authored	[InstanceEdit:9860856] May, Bruce, 2024-02-10
created	[InstanceEdit:9860923] May, Bruce, 2024-02-12
dbId	9860931
displayName	Response of endothelial cells to shear stress
edited	[InstanceEdit:9860856] May, Bruce, 2024-02-10
eventOf	[Pathway:R-HSA-9855142] Cellular responses to mechanical stimuli - Homo sapiens
figure	[Figure:9918390] /figures/ehld/R-HSA-9860931.svg
goBiologicalProcess	[GO_BiologicalProcess:528679] cellular response to endogenous stimulus
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Homo sapiens [Pathway:R-HSA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9858445] Mechanosensitive GPCRs and ion channels in shear stress sensing [LiteratureReference:9863130] Endothelial mechanobiology in atherosclerosis [LiteratureReference:9863134] Vascular mechanotransduction [LiteratureReference:9860922] Flow-induced�reprogramming of endothelial cells in atherosclerosis [LiteratureReference:9907255] Mechanosensing by Vascular Endothelium [LiteratureReference:9907250] Early events in endothelial flow sensing [LiteratureReference:9855162] Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity [LiteratureReference:9859304] Piezo1 integration of vascular architecture with physiological force [LiteratureReference:9862113] Structure, kinetic properties and biological function of mechanosensitive Piezo channels [LiteratureReference:9860495] A mechanosensory complex that mediates the endothelial cell response to fluid shear stress [LiteratureReference:9861297] Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure [LiteratureReference:9860797] P2Y? and Gq/G?? control blood pressure by mediating endothelial mechanotransduction [LiteratureReference:202117] Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation [LiteratureReference:9860803] Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation [LiteratureReference:9865220] Interaction between integrin ?5 and PDE4D regulates endothelial inflammatory signalling [LiteratureReference:9865292] Protein Phosphatase 2A Mediates YAP Activation in Endothelial Cells Upon VEGF Stimulation and Matrix Stiffness [LiteratureReference:9861479] Piezo1 and G_q/G₁₁ promote endothelial inflammation depending on flow pattern and integrin activation [LiteratureReference:9863598] Mechanosensing and Mechanosignal Transduction in Atherosclerosis
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Response of endothelial cells to shear stress
orthologousEvent	[Pathway:R-PFA-9860931] Response of endothelial cells to shear stress - Plasmodium falciparum [Pathway:R-SCE-9860931] Response of endothelial cells to shear stress - Saccharomyces cerevisiae [Pathway:R-SPO-9860931] Response of endothelial cells to shear stress - Schizosaccharomyces pombe [Pathway:R-DDI-9860931] Response of endothelial cells to shear stress - Dictyostelium discoideum [Pathway:R-CEL-9860931] Response of endothelial cells to shear stress - Caenorhabditis elegans [Pathway:R-DME-9860931] Response of endothelial cells to shear stress - Drosophila melanogaster [Pathway:R-GGA-9860931] Response of endothelial cells to shear stress - Gallus gallus [Pathway:R-XTR-9860931] Response of endothelial cells to shear stress - Xenopus tropicalis [Pathway:R-DRE-9860931] Response of endothelial cells to shear stress - Danio rerio [Pathway:R-SSC-9860931] Response of endothelial cells to shear stress - Sus scrofa [Pathway:R-BTA-9860931] Response of endothelial cells to shear stress - Bos taurus [Pathway:R-CFA-9860931] Response of endothelial cells to shear stress - Canis familiaris [Pathway:R-RNO-9860931] Response of endothelial cells to shear stress - Rattus norvegicus [Pathway:R-MMU-9860931] Response of endothelial cells to shear stress - Mus musculus
releaseDate	2024-09-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9860931
summation	[Summation:9907252] Vascular endothelial cells experience shear stress produced ...

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[Pathway:R-HSA-9855142] Cellular responses to mechanical stimuli

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