Reactome | Response of endothelial cells to shear stress

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Response of endothelial cells to shear stress Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911042
displayName	Response of endothelial cells to shear stress
eventOf	[Pathway:R-DME-9855142] Cellular responses to mechanical stimuli - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:528679] cellular response to endogenous stimulus
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DME-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Drosophila melanogaster [Pathway:R-DME-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-9860931] Response of endothelial cells to shear stress - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Response of endothelial cells to shear stress
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9860931
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9855142] Cellular responses to mechanical stimuli
(inferredTo)	[Pathway:R-HSA-9860931] Response of endothelial cells to shear stress

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