Reactome | MITF-M dimer binds the DICER1 gene

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MITF-M dimer binds the DICER1 gene Show undefined attributes

authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
category	binding
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9858402] Rothfels, Karen, 2024-01-12
dbId	9858401
displayName	MITF-M dimer binds the DICER1 gene
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
eventOf	[Pathway:R-HSA-9824594] Regulation of MITF-M-dependent genes involved in apoptosis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9858407] MITF-M dependent DICER1 gene expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8962962] DICER1 gene [nucleoplasm] [Complex:R-HSA-9825710] MITF-M dimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9856941] Lineage-specific transcriptional regulation of DICER by MITF in melanocytes [LiteratureReference:9858346] Accelerated disappearance of melanocytes in bcl-2-deficient mice [LiteratureReference:9858368] Bcl-2 overexpression in melanoma cells increases tumor progression-associated properties and in vivo tumor growth [LiteratureReference:9858355] Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM [LiteratureReference:9858375] Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage [LiteratureReference:9858363] Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters [LiteratureReference:8943362] Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes [LiteratureReference:9858364] miRiad roles for the miR-17-92 cluster in development and disease [LiteratureReference:9730403] MITF-the first 25 years
maxDepth	1
modified	[InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M dimer binds the DICER1 gene
output	[Complex:R-HSA-9858393] MITF-M dimer:DICER1 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9857375] MITF dimerizes - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9858401
summation	[Summation:9858399] MITF binds to promoter elements in the upstream regulatory r...

Referrals

(hasEvent)	[Pathway:R-HSA-9824594] Regulation of MITF-M-dependent genes involved in apoptosis
(precedingEvent)	[BlackBoxEvent:R-HSA-9858407] MITF-M dependent DICER1 gene expression