Reactome | PLK1 phosphorylates FIRMM at S744

Schema > Reaction > Entries

PLK1 phosphorylates FIRMM at S744 Show undefined attributes

authored	[InstanceEdit:9851977] Orlic-Milacic, Marija, 2023-11-02
catalystActivity	[CatalystActivity:9853435] protein serine/threonine kinase activity of p-S43-FIRRM:p-T210-PLK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9853378] Orlic-Milacic, Marija, 2023-11-15
dbId	9853369
displayName	PLK1 phosphorylates FIRMM at S744
edited	[InstanceEdit:9863557] Orlic-Milacic, Marija, 2024-03-01
eventOf	[Pathway:R-HSA-2500257] Resolution of Sister Chromatid Cohesion - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9851996] p-S43-FIRRM:p-T210-PLK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9851945] Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PLK1 phosphorylates FIRMM at S744
orthologousEvent	[Reaction:R-GGA-9853369] PLK1 phosphorylates FIRMM at S744 - Gallus gallus [Reaction:R-DRE-9853369] PLK1 phosphorylates FIRMM at S744 - Danio rerio [Reaction:R-SSC-9853369] PLK1 phosphorylates FIRMM at S744 - Sus scrofa [Reaction:R-BTA-9853369] PLK1 phosphorylates FIRMM at S744 - Bos taurus [Reaction:R-CFA-9853369] PLK1 phosphorylates FIRMM at S744 - Canis familiaris [Reaction:R-RNO-9853369] PLK1 phosphorylates FIRMM at S744 - Rattus norvegicus [Reaction:R-MMU-9853369] PLK1 phosphorylates FIRMM at S744 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-9853437] p-S43,S744-FIRRM [cytosol] [EntityWithAccessionedSequence:R-HSA-3000318] p-T210-PLK1 [cytosol]
precedingEvent	[Reaction:R-HSA-9851972] PLK1 phosphorylates FIRRM at S43 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863560] Liu, Xing, 2024-03-01 [InstanceEdit:9863558] Yao, Xuebiao, 2024-03-01 [InstanceEdit:9909004] Orthwein, Alexandre, 2024-04-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9853369
summation	[Summation:9853446] PLK1 phosphorylates FIRRM (also known as Apolo1 or FLIP or C...
updateTrackers	[UpdateTracker:9911043] Update Tracker - [Reaction:9853369] PLK1 phosphorylates FIRMM at S744 - v89:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9911043] Update Tracker - [Reaction:9853369] PLK1 phosphorylates FIRMM at S744 - v89:[modifyText]
(precedingEvent)	[NegativePrecedingEvent:9910669] Futile Cycle: PLK1 phosphorylates FIRMM at S744 [NegativePrecedingEvent:9910670] Futile Cycle: PLK1 phosphorylates FIRMM at S744 [NegativePrecedingEvent:9910671] Futile Cycle: PLK1 phosphorylates FIRMM at S744 [NegativePrecedingEvent:9910667] Futile Cycle: PLK1 phosphorylates FIRMM at S744 [NegativePrecedingEvent:9910666] Futile Cycle: PLK1 phosphorylates FIRMM at S744
(hasEvent)	[Pathway:R-HSA-2500257] Resolution of Sister Chromatid Cohesion