Reactome | B3GNT5 transfers GlcNAc to LacCer

Schema > Reaction > Entries

B3GNT5 transfers GlcNAc to LacCer Show undefined attributes

authored	[InstanceEdit:9846482] Stephan, Ralf, 2023-10-11
catalystActivity	[CatalystActivity:9846493] lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity of B3GNT5 [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:9846494] Stephan, Ralf, 2023-10-11
crossReference	[DatabaseIdentifier:12667874] RHEA:13905
dbId	9846501
displayName	B3GNT5 transfers GlcNAc to LacCer
edited	[InstanceEdit:9851336] Stephan, Ralf, 2023-10-23
eventOf	[Pathway:R-HSA-9840309] Glycosphingolipid biosynthesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9850731] Vesicles transport GSL from Golgi to plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-9844874] LacCer-d18 [Golgi membrane] [SimpleEntity:R-ALL-914003] UDP-GlcNAc [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:977049] Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids [LiteratureReference:9846497] Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	B3GNT5 transfers GlcNAc to LacCer
orthologousEvent	[Reaction:R-CEL-9846501] B3GNT5 transfers GlcNAc to LacCer - Caenorhabditis elegans [Reaction:R-DME-9846501] B3GNT5 transfers GlcNAc to LacCer - Drosophila melanogaster [Reaction:R-GGA-9846501] B3GNT5 transfers GlcNAc to LacCer - Gallus gallus [Reaction:R-XTR-9846501] B3GNT5 transfers GlcNAc to LacCer - Xenopus tropicalis [Reaction:R-DRE-9846501] B3GNT5 transfers GlcNAc to LacCer - Danio rerio [Reaction:R-SSC-9846501] B3GNT5 transfers GlcNAc to LacCer - Sus scrofa [Reaction:R-BTA-9846501] B3GNT5 transfers GlcNAc to LacCer - Bos taurus [Reaction:R-RNO-9846501] B3GNT5 transfers GlcNAc to LacCer - Rattus norvegicus [Reaction:R-MMU-9846501] B3GNT5 transfers GlcNAc to LacCer - Mus musculus
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-9846503] Lc3Cer [Golgi membrane] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-9851347] B4GALT5/6 transfer Gal to GlcCer - Homo sapiens
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9846501
summation	[Summation:9846505] Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9850731] Vesicles transport GSL from Golgi to plasma membrane
(hasEvent)	[Pathway:R-HSA-9840309] Glycosphingolipid biosynthesis