Reactome | PLEKHA8 catalyzes transport of GlcCer to plasma membrane

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PLEKHA8 catalyzes transport of GlcCer to plasma membrane Show undefined attributes

authored	[InstanceEdit:9844978] Stephan, Ralf, 2023-09-25
catalystActivity	[CatalystActivity:9845063] glycolipid transfer activity of ARF1:PLEKHA8:PI4P dimer [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:876] plasma membrane
created	[InstanceEdit:9845048] Stephan, Ralf, 2023-09-26
crossReference	[DatabaseIdentifier:12668085] RHEA:77259
dbId	9845055
displayName	PLEKHA8 catalyzes transport of GlcCer to plasma membrane
edited	[InstanceEdit:9851336] Stephan, Ralf, 2023-10-23
eventOf	[Pathway:R-HSA-9845576] Glycosphingolipid transport - Homo sapiens
input	[SimpleEntity:R-ALL-1660674] GlcCer [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1675789] FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P [LiteratureReference:9845061] FAPP2 is involved in the transport of apical cargo in polarized MDCK cells [LiteratureReference:9845064] Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide [LiteratureReference:9845056] Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins [LiteratureReference:9845049] Golgi protein FAPP2 tubulates membranes
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PLEKHA8 catalyzes transport of GlcCer to plasma membrane
orthologousEvent	[Reaction:R-BTA-9845055] PLEKHA8 catalyzes transport of GlcCer to plasma membrane - Bos taurus [Reaction:R-PFA-9845055] PLEKHA8 catalyzes transport of GlcCer to plasma membrane - Plasmodium falciparum [Reaction:R-CEL-9845055] PLEKHA8 catalyzes transport of GlcCer to plasma membrane - Caenorhabditis elegans [Reaction:R-DME-9845055] PLEKHA8 catalyzes transport of GlcCer to plasma membrane - Drosophila melanogaster [Reaction:R-XTR-9845055] PLEKHA8 catalyzes transport of GlcCer to plasma membrane - Xenopus tropicalis [Reaction:R-DRE-9845055] PLEKHA8 catalyzes transport of GlcCer to plasma membrane - Danio rerio [Reaction:R-SSC-9845055] PLEKHA8 catalyzes transport of GlcCer to plasma membrane - Sus scrofa [Reaction:R-CFA-9845055] PLEKHA8 catalyzes transport of GlcCer to plasma membrane - Canis familiaris [Reaction:R-RNO-9845055] PLEKHA8 catalyzes transport of GlcCer to plasma membrane - Rattus norvegicus [Reaction:R-MMU-9845055] PLEKHA8 catalyzes transport of GlcCer to plasma membrane - Mus musculus
output	[SimpleEntity:R-ALL-1861782] GlcCer [plasma membrane]
precedingEvent	[Reaction:R-HSA-1638104] UGCG transfers glucose to ceramide - Homo sapiens
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9845055
summation	[Summation:9845047] Dimeric pleckstrin homology domain-containing family A membe...

Referrals

(hasEvent)

[Pathway:R-HSA-9845576] Glycosphingolipid transport