Reactome | PLEKHA8 catalyzes transport of GlcCer to plasma membrane

PLEKHA8 catalyzes transport of GlcCer to plasma membrane

Stable Identifier

R-HSA-9845055

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, plasma membrane

ReviewStatus

5/5

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PLEKHA8 catalyzes transport of GlcCer to plasma membrane

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Dimeric pleckstrin homology domain-containing family A member 8 (PLEKHA8, FAPP2) controls the transfer of GlcCer from the cis-Golgi to the trans-Golgi membrane. PLEKHA8 transport depends on binding to phosphatidylinositol 4-phosphate (PtdIns4P) and the small GTPase ARF1 (Godi et al., 2004; Vieira et al., 2005; D'Angelo et al., 2007; reviewed by Yamaji & Hanada, 2015). PLEKHA8 complex also forms tubules from membrane sheets. GlcCer reaches the plasma membrane via non-vesicular transport from the trans-Golgi, i.e., using tubular structures (Cao et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19940249	Golgi protein FAPP2 tubulates membranes Cao, X, Coskun, U, Rössle, M, Buschhorn, SB, Grzybek, M, Dafforn, TR, Lenoir, M, Overduin, M, Simons, K	Proc Natl Acad Sci U S A	2009
17687330	Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide D'Angelo, G, Polishchuk, E, Di Tullio, G, Santoro, M, Di Campli, A, Godi, A, West, G, Bielawski, J, Chuang, CC, van der Spoel, AC, Platt, FM, Hannun, YA, Polishchuk, R, Mattjus, P, De Matteis, MA	Nature	2007
25382749	Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins Yamaji, T, Hanada, K	Traffic	2015
15107860	FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P Godi, A, Di Campli, A, Konstantakopoulos, A, Di Tullio, G, Alessi, DR, Kular, GS, Daniele, T, Marra, P, Lucocq, JM, De Matteis, MA	Nat Cell Biol	2004
16103222	FAPP2 is involved in the transport of apical cargo in polarized MDCK cells Vieira, OV, Verkade, P, Manninen, A, Simons, K	J Cell Biol	2005