Reactome | Active LTK recruits GRB2:SOS1

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Active LTK recruits GRB2:SOS1 Show undefined attributes

authored	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9842653] Rothfels, Karen, 2023-08-27
dbId	9842669
displayName	Active LTK recruits GRB2:SOS1
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-9842663] Signaling by LTK - Homo sapiens
input	[Complex:R-HSA-9842606] Active LTK:p-3Y SHC1 [plasma membrane] [Complex:R-HSA-9842593] GRB2:SOS1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9842507] An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway [LiteratureReference:9842473] Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase [LiteratureReference:9842439] Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth [LiteratureReference:9842429] ALK-activating homologous mutations in LTK induce cellular transformation [LiteratureReference:9842463] MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Active LTK recruits GRB2:SOS1
orthologousEvent	[Reaction:R-GGA-9842669] Active LTK recruits GRB2:SOS1 - Gallus gallus [Reaction:R-XTR-9842669] Active LTK recruits GRB2:SOS1 - Xenopus tropicalis [Reaction:R-RNO-9842669] Active LTK recruits GRB2:SOS1 - Rattus norvegicus [Reaction:R-MMU-9842669] Active LTK recruits GRB2:SOS1 - Mus musculus
output	[Complex:R-HSA-9842607] Active LTK:p-3Y SHC1:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9842651] Active LTK receptor phosphorylates SHC1 - Homo sapiens
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9842669
summation	[Summation:9842654] MAPK phosphorylation is observed downstream of both activate...

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[Pathway:R-HSA-9842663] Signaling by LTK