MAPK phosphorylation is observed downstream of both activate...

created [InstanceEdit:9842653] Rothfels, Karen, 2023-08-27
dbId 9842654
displayName MAPK phosphorylation is observed downstream of both activate...
modified [InstanceEdit:9845081] Rothfels, Karen, 2023-09-26
schemaClass Summation
text MAPK phosphorylation is observed downstream of both activated full length LTK and activated chimeric receptors of LTK (Ueno et al, 1995; Ueno et al, 1996; Yamada et al, 2008; Farhan et al, 2010; Roll and Reuther, 2012).
Binding site studies with chimeric proteins identified two NPXY sites in LTK that appear to contribute to MAPK signaling, one at the C-terminus including the SHC-binding Y862 and one closer to the juxtamembrane region, that appears to recruit IRS1. Co-immunoprecipitation studies show that GRB2 and SOS1 are pulled down with SHC1 and the activated EGFR-LTK and CSF1R-LTK receptor chimeras (Ueno et al, 1995; Ueno et al, 1996). Mutation of the SHC binding site Y862 decreases signaling through the MAPK pathway, suggesting that the complex assembled at this docking site contributes to the phosphorylation of MAPK proteins and mitogenic signaling (Ueno et al, 1996).
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